Version 5.4
Mus musculus Gene: Fbxl12
Summary
InnateDB Gene IDBG-137299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl12
Gene Name F-box and leucine-rich repeat protein 12
Synonyms 3110048D16Rik; Fbl12
Species Mus musculus
Ensembl Gene ENSMUSG00000066892
Encoded Proteins
IDBP-137301
F-box and leucine-rich repeat protein 12
IDBP-137303
F-box and leucine-rich repeat protein 12
IDBP-536577
F-box and leucine-rich repeat protein 12
IDBP-534595
F-box and leucine-rich repeat protein 12
IDBP-533944
F-box and leucine-rich repeat protein 12
IDBP-539801
F-box and leucine-rich repeat protein 12
IDBP-538287
F-box and leucine-rich repeat protein 12
IDBP-535650
F-box and leucine-rich repeat protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127452:
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:20618118-20644767
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000086458 ENSMUSP00000083649
ENSMUST00000086459 ENSMUSP00000083650
ENSMUST00000155301 ENSMUSP00000118369
ENSMUST00000155280
ENSMUST00000131128 ENSMUSP00000115058
ENSMUST00000148631 ENSMUSP00000119124
ENSMUST00000140702 ENSMUSP00000114466
ENSMUST00000151861 ENSMUSP00000121429
ENSMUST00000131343 ENSMUSP00000118873
ENSMUST00000153154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127452
View Gene Order
ENSBTAG00000025148
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24608 Mm.399590 Mm.489685
RefSeq NM_001002846 NM_001286529 NM_013911 XM_006510397 XM_006510398 XM_006510399
OMIM
CCDS CCDS22880 CCDS22881
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca