InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Angpt2

Summary

InnateDB Gene

IDBG-137356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Angpt2

Gene Name

angiopoietin 2

Synonyms

Agpt2; Ang-2; Ang2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031465

Encoded Proteins

IDBP-137358

angiopoietin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:18690263-18741562

Strand

Reverse strand

Band

A1.3

Transcripts

ENSMUST00000033846	ENSMUSP00000033846
ENSMUST00000170200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001974	blood vessel remodeling
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007281	germ cell development
GO:0007492	endoderm development
GO:0009314	response to radiation
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0016525	negative regulation of angiogenesis
GO:0030097	hemopoiesis
GO:0031100	organ regeneration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0048014	Tie signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0050928	negative regulation of positive chemotaxis
GO:0060135	maternal process involved in female pregnancy
GO:0071363	cellular response to growth factor stimulus
GO:0072012	glomerulus vasculature development