Version 5.4
Mus musculus Gene: Eps8l1
Summary
InnateDB Gene IDBG-137784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eps8l1
Gene Name EPS8-like 1
Synonyms 2310051G19Rik; 4632407K17Rik; AW060268; DRC3; EPS8R1
Species Mus musculus
Ensembl Gene ENSMUSG00000006154
Encoded Proteins
IDBP-137786
EPS8-like 1
IDBP-628179
EPS8-like 1
IDBP-628180
EPS8-like 1
IDBP-628183
EPS8-like 1
IDBP-628184
EPS8-like 1
IDBP-628185
EPS8-like 1
IDBP-628187
EPS8-like 1
IDBP-628188
EPS8-like 1
IDBP-628190
EPS8-like 1
IDBP-628191
EPS8-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131037:
This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4460674-4479404
Strand Forward strand
Band A1
Transcripts
ENSMUST00000086372 ENSMUSP00000083559
ENSMUST00000163804 ENSMUSP00000133102
ENSMUST00000167298 ENSMUSP00000133142
ENSMUST00000171445 ENSMUSP00000133206
ENSMUST00000167810 ENSMUSP00000126720
ENSMUST00000170423
ENSMUST00000167599
ENSMUST00000169820 ENSMUSP00000131773
ENSMUST00000163893 ENSMUSP00000125840
ENSMUST00000163137 ENSMUSP00000131345
ENSMUST00000170635 ENSMUSP00000127999
ENSMUST00000167068
ENSMUST00000168924
ENSMUST00000164987 ENSMUSP00000130665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0042608 T cell receptor binding
GO:0051015 actin filament binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0016601 Rac protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131037
View Gene Order
ENSBTAG00000009512
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.360392
RefSeq NM_001290416 NM_026146 XM_006540323 XM_006540326
OMIM
CCDS CCDS20736
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca