Homo sapiens Gene: TNFRSF1A
Summary
InnateDB Gene IDBG-13807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF1A
Gene Name tumor necrosis factor receptor superfamily, member 1A
Synonyms CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55; TNFR60;
Species Homo sapiens
Ensembl Gene ENSG00000067182
Encoded Proteins
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
tumor necrosis factor receptor superfamily, member 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
TNFR1 mediates TRAF2 phosphorylation and recruitment of the IKK complex
TNFRSF1A modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the IL6 and NFkB signalling pathway. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tnfrsf1a modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the Il6 and NFkB signalling pathway.
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6328757-6342114
Strand Reverse strand
Band p13.31
Transcripts
ENST00000162749 ENSP00000162749
ENST00000366159 ENSP00000380389
ENST00000440083 ENSP00000413224
ENST00000437813
ENST00000534885 ENSP00000441803
ENST00000536717
ENST00000543995 ENSP00000442405
ENST00000540022 ENSP00000438343
ENST00000543359
ENST00000537842
ENST00000535038
ENST00000539372 ENSP00000442059
ENST00000543048 ENSP00000439981
ENST00000536194 ENSP00000442919
ENST00000535958
ENST00000538363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 168 [view]
Protein-Protein 165 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043120 tumor necrosis factor binding
Biological Process
GO:0001666 response to hypoxia
GO:0006693 prostaglandin metabolic process
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009611 response to wounding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032715 negative regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033013 tetrapyrrole metabolic process
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0043279 response to alkaloid
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051291 protein heterooligomerization
GO:0071260 cellular response to mechanical stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0030424 axon
GO:0043234 protein complex
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Extrinsic Pathway for Apoptosis pathway
Apoptosis pathway
TNF signaling pathway
Death Receptor Signalling pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
Osteoclast differentiation pathway
Adipocytokine signaling pathway pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
INOH
TNFR1 signaling pathway pathway
PID BIOCARTA
Nf-kb signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Sodd/tnfr1 signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
PID NCI
Ceramide signaling pathway
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
Signaling events mediated by HDAC Class I
Canonical NF-kappaB pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt P19438
TrEMBL F5H4T5 J9PH39
UniProt Splice Variant
Entrez Gene 7132
UniGene Hs.279594
RefSeq NM_001065
HUGO HGNC:11916
OMIM 191190
CCDS CCDS8542
HPRD 01861
IMGT
EMBL AC006057 AK056611 AK291088 AK298729 AK304517 AK315509 AY131997 BC010140 CH471116 EU927389 JN172914 M33294 M58286 M60275 M63121 M75864 M75865 M75866 X55313
GenPept AAA03210 AAA36753 AAA36754 AAA36756 AAA61201 AAH10140 AAM77802 ACH57451 AEO89726 BAF83777 BAG37891 BAG51763 BAG60879 BAG65321 CAA39021 EAW88805 EAW88806
RNA Seq Atlas 7132