Version 5.4
Mus musculus Gene: Cacnb2
Summary
InnateDB Gene IDBG-138441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacnb2
Gene Name calcium channel, voltage-dependent, beta 2 subunit
Synonyms AW060387; CAB2; Cavbeta2; Cchb2
Species Mus musculus
Ensembl Gene ENSMUSG00000057914
Encoded Proteins
IDBP-251161
calcium channel, voltage-dependent, beta 2 subunit
IDBP-251167
calcium channel, voltage-dependent, beta 2 subunit
IDBP-251169
calcium channel, voltage-dependent, beta 2 subunit
IDBP-538742
calcium channel, voltage-dependent, beta 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165995:
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:14604306-14987908
Strand Forward strand
Band A2
Transcripts
ENSMUST00000114723 ENSMUSP00000110371
ENSMUST00000114719 ENSMUSP00000110367
ENSMUST00000114718 ENSMUSP00000110366
ENSMUST00000148676
ENSMUST00000156027 ENSMUSP00000115262
ENSMUST00000137746
ENSMUST00000123719
ENSMUST00000144423
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0007268 synaptic transmission
GO:0007601 visual perception
GO:0034765 regulation of ion transmembrane transport
GO:0051928 positive regulation of calcium ion transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165995
View Gene Order
ENSBTAG00000022000
Not yet available
Pathways
NETPATH
REACTOME
REACT_217323
Integration of energy metabolism pathway
REACT_236183
NCAM1 interactions pathway
REACT_188937
Metabolism pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_261444
Axon guidance pathway
REACT_225645
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
KEGG
mmu04010
MAPK signaling pathway pathway
mmu04260
Cardiac muscle contraction pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
REACT_220819
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_217282
NCAM signaling for neurite out-growth pathway
REACT_202514
NCAM1 interactions pathway
REACT_217101
Integration of energy metabolism pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_203140
Axon guidance pathway
REACT_225032
Neuronal System pathway
REACT_219139
Metabolism pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.313930 Mm.397016 Mm.490702
RefSeq NM_001252533 NM_023116 XM_006497313 XM_006497314 XM_006497315 XM_006497316 XM_006497319 XM_006497320 XM_006497323
OMIM
CCDS CCDS15702
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca