Mus musculus Gene: Mllt4
Summary
InnateDB Gene IDBG-138450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mllt4
Gene Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Synonyms 5033403D15Rik; Af-6; AF6; Afadin; Gm314; I-afadin; S-afadin;
Species Mus musculus
Ensembl Gene ENSMUSG00000068036
Encoded Proteins
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130396:
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:13760539-13906150
Strand Forward strand
Band A1
Transcripts
ENSMUST00000139347 ENSMUSP00000115250
ENSMUST00000156591 ENSMUSP00000122204
ENSMUST00000139666 ENSMUSP00000118318
ENSMUST00000137784 ENSMUSP00000119153
ENSMUST00000137708 ENSMUSP00000114485
ENSMUST00000150848 ENSMUSP00000122447
ENSMUST00000137495
ENSMUST00000137503
ENSMUST00000141640
ENSMUST00000136087
ENSMUST00000123030
ENSMUST00000137531 ENSMUSP00000116711
ENSMUST00000124188
ENSMUST00000133422
ENSMUST00000124922
ENSMUST00000170827 ENSMUSP00000128891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0030054 cell junction
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cell-cell junction organization pathway
Adherens junctions interactions pathway
Cell junction organization pathway
Cell-Cell communication pathway
KEGG
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
INOH
PID BIOCARTA
PID NCI
E-cadherin signaling in the nascent adherens junction
Nectin adhesion pathway
SHP2 signaling
Stabilization and expansion of the E-cadherin adherens junction
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.479700 Mm.59167
RefSeq NM_010806 XM_006523752 XM_006523753 XM_006523754 XM_006523755 XM_006523756 XM_006523757 XM_006523758 XM_006523763 XM_006523764 XM_006523765 XM_006523766
OMIM
CCDS CCDS49955
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas