Version 5.4
Mus musculus Gene: Ccna2
Summary
InnateDB Gene IDBG-138776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccna2
Gene Name cyclin A2
Synonyms AA408589; Ccn-1; Ccn1; Ccna; Cyca; CycA2
Species Mus musculus
Ensembl Gene ENSMUSG00000027715
Encoded Proteins
IDBP-138778
cyclin A2
IDBP-537750
cyclin A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25005359
[Homo sapiens] Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145386:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:36564866-36572150
Strand Reverse strand
Band B
Transcripts
ENSMUST00000029270 ENSMUSP00000029270
ENSMUST00000156575
ENSMUST00000147380 ENSMUSP00000118239
ENSMUST00000145309
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007067 mitotic nuclear division
GO:0007265 Ras protein signal transduction
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0031100 organ regeneration
GO:0032355 response to estradiol
GO:0033762 response to glucagon
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145386
View Gene Order
ENSBTAG00000004943
Not yet available
Pathways
NETPATH
REACTOME
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_227891
G2 Phase pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188957
Cellular responses to stress pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_199110
G0 and Early G1 pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_255479
Regulation of DNA replication pathway
REACT_188820
Cellular Senescence pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_206803
Cyclin A/B1 associated events during G2/M transition pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_220647
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_253623
S Phase pathway
KEGG
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_111214
G0 and Early G1 pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_1915
G2 Phase pathway
REACT_6362
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_383
DNA Replication pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_829
Regulation of DNA replication pathway
REACT_223914
G2/M Transition pathway
REACT_226948
G0 and Early G1 pathway
REACT_225014
S Phase pathway
REACT_201949
G2 Phase pathway
REACT_213075
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_224007
Cyclin A/B1 associated events during G2/M transition pathway
REACT_213604
DNA Replication pathway
REACT_211609
G1/S Transition pathway
REACT_212671
Regulation of DNA replication pathway
REACT_213030
Orc1 removal from chromatin pathway
REACT_206069
Cellular responses to stress pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_226495
Cyclin E associated events during G1/S transition pathway
REACT_223494
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_212154
Regulation of mitotic cell cycle pathway
REACT_206864
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_218054
APC/C-mediated degradation of cell cycle proteins pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_205537
Removal of licensing factors from origins pathway
REACT_214732
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_222483
Switching of origins to a post-replicative state pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
rb_1pathway
Regulation of retinoblastoma protein
atf2_pathway
ATF-2 transcription factor network
p53regulationpathway
p53 pathway
p73pathway
p73 transcription factor network
e2f_pathway
E2F transcription factor network
prlsignalingeventspathway
Signaling events mediated by PRL
il2_stat5pathway
IL2 signaling events mediated by STAT5
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4189 Mm.488811
RefSeq NM_009828
OMIM
CCDS CCDS17313
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca