InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdc37

Summary

InnateDB Gene

IDBG-139272.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc37

Gene Name

cell division cycle 37

Synonyms

p50; p50Cdc37

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019471

Encoded Proteins

IDBP-139274

cell division cycle 37 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105401:
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21138541-21149906

Strand

Reverse strand

Band

Transcripts

ENSMUST00000019615

ENSMUSP00000019615

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 150 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	150 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031072	heat shock protein binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0043422	protein kinase B binding
GO:0051087	chaperone binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0051726	regulation of cell cycle
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway