InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde4a

Summary

InnateDB Gene

IDBG-139354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4a

Gene Name

phosphodiesterase 4A, cAMP specific

Synonyms

D9Ertd60e; Dpde2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032177

Encoded Proteins

IDBP-139356

phosphodiesterase 4A, cAMP specific

IDBP-139360

phosphodiesterase 4A, cAMP specific

IDBP-249591

phosphodiesterase 4A, cAMP specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065989:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21165714-21213248

Strand

Forward strand

Band

Transcripts

ENSMUST00000039413	ENSMUSP00000037025
ENSMUST00000003395	ENSMUSP00000003395
ENSMUST00000115458	ENSMUSP00000111118
ENSMUST00000131769
ENSMUST00000140440
ENSMUST00000127821

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007608	sensory perception of smell
GO:0010738	regulation of protein kinase A signaling
GO:0035690	cellular response to drug
GO:0043949	regulation of cAMP-mediated signaling