InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: S1pr5

Summary

InnateDB Gene

IDBG-139595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr5

Gene Name

sphingosine-1-phosphate receptor 5

Synonyms

Edg8; lpB4; S1P5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045087

Encoded Proteins

IDBP-401605

sphingosine-1-phosphate receptor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180739:
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21242912-21248443

Strand

Reverse strand

Band

Transcripts

ENSMUST00000122088

ENSMUSP00000113843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045664	regulation of neuron differentiation