Version 5.4
Mus musculus Gene: Epn1
Summary
InnateDB Gene IDBG-139957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epn1
Gene Name epsin 1
Synonyms AA269831; Ibp1
Species Mus musculus
Ensembl Gene ENSMUSG00000035203
Encoded Proteins
IDBP-139959
epsin 1
IDBP-139961
epsin 1
IDBP-534627
epsin 1
IDBP-532323
epsin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063245:
The protein encoded by this gene binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5080235-5098178
Strand Forward strand
Band A1
Transcripts
ENSMUST00000045277 ENSMUSP00000043340
ENSMUST00000098845 ENSMUSP00000096445
ENSMUST00000146317 ENSMUSP00000116571
ENSMUST00000153169 ENSMUSP00000122594
ENSMUST00000152083
ENSMUST00000155436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005543 phospholipid binding
GO:0008134 transcription factor binding
GO:0008289 lipid binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006897 endocytosis
GO:0007219 Notch signaling pathway
GO:0007565 female pregnancy
GO:0048568 embryonic organ development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 coated pit
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000063245
View Gene Order
ENSBTAG00000046996
Not yet available
Pathways
NETPATH
REACTOME
REACT_203917
EGFR downregulation pathway
REACT_189085
Disease pathway
REACT_242976
Signaling by EGFR pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
erbb1_internalization_pathway
Internalization of ErbB1
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3091 Mm.490070
RefSeq NM_001252454 NM_010147 XM_006539529 XM_006539530 XM_006539531 XM_006539533 XM_006539534 XM_006539536 XM_006539537 XM_006539538
OMIM
CCDS CCDS20758
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca