Version 5.4
Mus musculus Gene: Il21
Summary
InnateDB Gene IDBG-140267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il21
Gene Name interleukin 21
Synonyms IL-21
Species Mus musculus
Ensembl Gene ENSMUSG00000027718
Encoded Proteins
IDBP-140269
interleukin 21
IDBP-538228
interleukin 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23453633
IL21 induces apoptosis of conventional dendritic cells.
InnateDB Annotation from Orthologs
Summary
PMID 20817119
[Homo sapiens] IL21 is a cytokine that has broad effects on both innate and adaptive immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138684:
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:37222759-37232618
Strand Reverse strand
Band B
Transcripts
ENSMUST00000029273 ENSMUSP00000029273
ENSMUST00000161015 ENSMUSP00000124668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 0
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005134 interleukin-2 receptor binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0032733 positive regulation of interleukin-10 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045579 positive regulation of B cell differentiation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0048469 cell maturation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138684
View Gene Order
ENSBTAG00000012368
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.157689
RefSeq NM_001291041 NM_021782 XM_006535513
OMIM
CCDS CCDS17317 CCDS71236
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca