Version 5.4
Mus musculus Gene: Nos3
Summary
InnateDB Gene IDBG-140461.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nos3
Gene Name nitric oxide synthase 3, endothelial cell
Synonyms 2310065A03Rik; ecNOS; eNOS; Nos-3
Species Mus musculus
Ensembl Gene ENSMUSG00000028978
Encoded Proteins
IDBP-140463
nitric oxide synthase 3, endothelial cell
IDBP-250382
nitric oxide synthase 3, endothelial cell
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164867:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:24364810-24384474
Strand Forward strand
Band A3
Transcripts
ENSMUST00000030834 ENSMUSP00000030834
ENSMUST00000115090 ENSMUSP00000110742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004517 nitric-oxide synthase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001701 in utero embryonic development
GO:0001974 blood vessel remodeling
GO:0002028 regulation of sodium ion transport
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0014740 negative regulation of muscle hyperplasia
GO:0014806 smooth muscle hyperplasia
GO:0030324 lung development
GO:0031284 positive regulation of guanylate cyclase activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0034405 response to fluid shear stress
GO:0043267 negative regulation of potassium ion transport
GO:0043542 endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0050880 regulation of blood vessel size
GO:0051346 negative regulation of hydrolase activity
GO:0051926 negative regulation of calcium ion transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164867
View Gene Order
ENSBTAG00000017680
Not yet available
Pathways
NETPATH
REACTOME
REACT_199047
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_226405
NOSIP mediated eNOS trafficking pathway
REACT_189085
Disease pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_204801
eNOS activation and regulation pathway
REACT_221264
eNOS activation pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_227951
Signaling by VEGF pathway
REACT_198345
Phagosomal maturation (early endosomal stage) pathway
REACT_198347
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_188937
Metabolism pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_245499
Nitric oxide stimulates guanylate cyclase pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04370
VEGF signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_22
Leptin pathway
REACTOME
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_12510
NOSIP mediated eNOS trafficking pathway
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_12477
eNOS activation pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12529
Signaling by VEGF pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_111217
Metabolism pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa00330
Arginine and proline metabolism pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
shp2_pathway
SHP2 signaling
vegfr1_pathway
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.258415
RefSeq NM_008713 XM_006535639
OMIM
CCDS CCDS19117
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca