InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Appl1

Summary

InnateDB Gene

IDBG-140679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Appl1

Gene Name

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Synonyms

2900057D21Rik; 7330406P05Rik; AI585782; AW209077; BB022931; C88264; DIP13

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040760

Encoded Proteins

IDBP-140681

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157500:
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:26918988-26971232

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036570	ENSMUSP00000042875
ENSMUST00000141599
ENSMUST00000142645
ENSMUST00000142261

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043422	protein kinase B binding

Biological Process

GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0046324	regulation of glucose import
GO:0090003	regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0016581	NuRD complex
GO:0031901	early endosome membrane
GO:0070062	extracellular vesicular exosome