Version 5.4
Mus musculus Gene: Abcb8
Summary
InnateDB Gene IDBG-140806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abcb8
Gene Name ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms 4833412N02Rik; AA409895
Species Mus musculus
Ensembl Gene ENSMUSG00000028973
Encoded Proteins
IDBP-140808
ATP-binding cassette, sub-family B (MDR/TAP), member 8
IDBP-250427
ATP-binding cassette, sub-family B (MDR/TAP), member 8
IDBP-250429
ATP-binding cassette, sub-family B (MDR/TAP), member 8
IDBP-533478
ATP-binding cassette, sub-family B (MDR/TAP), member 8
IDBP-542159
ATP-binding cassette, sub-family B (MDR/TAP), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197150:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:24393663-24410054
Strand Forward strand
Band A3
Transcripts
ENSMUST00000073076 ENSMUSP00000072826
ENSMUST00000115077 ENSMUSP00000110729
ENSMUST00000115074 ENSMUSP00000110726
ENSMUST00000138168 ENSMUSP00000119791
ENSMUST00000136414
ENSMUST00000127816
ENSMUST00000136459
ENSMUST00000151535 ENSMUSP00000114767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197150
View Gene Order
ENSBTAG00000007759
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu02010
ABC transporters pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111108
Mitochondrial ABC transporters pathway
REACT_15480
ABC-family proteins mediated transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
KEGG
hsa02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt Q9CXJ4
TrEMBL D3Z1J6 D3Z492
UniProt Splice Variant
Entrez Gene 74610
UniGene Mm.283914
RefSeq NM_029020 XM_006535812
OMIM
CCDS CCDS19118
HPRD
IMGT
MGI ID MGI:1351667
MGI Symbol Abcb8
EMBL AC113055 AK014319 AK030624 AK049152 AK076315 AK166704 BC015301
GenPept AAH15301 BAB29270 BAC27052 BAC33571 BAC36297 BAE38958
RNA Seq Atlas 74610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca