Version 5.4
Mus musculus Gene: Il17rd
Summary
InnateDB Gene IDBG-140856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il17rd
Gene Name interleukin 17 receptor D
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040717
Encoded Proteins
IDBP-140858
interleukin 17 receptor D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25808990
Intracellular Sef/IL-17R (SEFIR) domain of Il17rd targets TIR adaptor proteins Myd88, Tirap, Ticam1, Ticam2 and Traf6 to inhibit TLR downstream signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144730:
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367). [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:27039001-27107286
Strand Forward strand
Band A3
Transcripts
ENSMUST00000035336 ENSMUSP00000036076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144730
View Gene Order
ENSBTAG00000010999
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
KEGG
INOH
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt Q8JZL1
TrEMBL
UniProt Splice Variant
Entrez Gene 171463
UniGene Mm.206726
RefSeq NM_134437 XM_006518667 XM_006518668
OMIM
CCDS CCDS26885
HPRD
IMGT
MGI ID MGI:2159727
MGI Symbol Il17rd
EMBL AF424804 AF459444 AF494209 AF494210 BC138629
GenPept AAI38630 AAL79530 AAM28441 AAM74078 AAM74079
RNA Seq Atlas 171463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca