Version 5.4
Mus musculus Gene: Thoc2
Summary
InnateDB Gene IDBG-140859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thoc2
Gene Name THO complex 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037475
Encoded Proteins
IDBP-140863
THO complex 2
IDBP-533003
THO complex 2
IDBP-539687
THO complex 2
IDBP-534628
THO complex 2
IDBP-536832
THO complex 2
IDBP-537159
THO complex 2
IDBP-542325
THO complex 2
IDBP-532910
THO complex 2
IDBP-534303
THO complex 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125676:
The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:41794991-41920674
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000047037 ENSMUSP00000044677
ENSMUST00000124458 ENSMUSP00000119460
ENSMUST00000151430 ENSMUSP00000115815
ENSMUST00000145586 ENSMUSP00000118960
ENSMUST00000143557 ENSMUSP00000118106
ENSMUST00000155369 ENSMUSP00000120342
ENSMUST00000134084
ENSMUST00000130993
ENSMUST00000123512
ENSMUST00000150443
ENSMUST00000151802
ENSMUST00000127338
ENSMUST00000129915 ENSMUSP00000121941
ENSMUST00000152921 ENSMUSP00000114148
ENSMUST00000131259 ENSMUSP00000119823
ENSMUST00000151454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001824 blastocyst development
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010468 regulation of gene expression
GO:0010793 regulation of mRNA export from nucleus
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0017145 stem cell division
GO:0046784 intronless viral mRNA export from host nucleus
Cellular Component
GO:0000445 THO complex part of transcription export complex
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000125676
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.259498 Mm.422930
RefSeq NM_001033422 XM_006541504
OMIM
CCDS CCDS40951
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca