Version 5.4
Mus musculus Gene: Dusp18
Summary
InnateDB Gene IDBG-141154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp18
Gene Name dual specificity phosphatase 18
Synonyms 4930527G07Rik; AI430870; BB028064; DSP18; DUSP20; LMWDSP20
Species Mus musculus
Ensembl Gene ENSMUSG00000047205
Encoded Proteins
IDBP-141156
dual specificity phosphatase 18
IDBP-261207
dual specificity phosphatase 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167065:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:3895240-3901296
Strand Forward strand
Band A1
Transcripts
ENSMUST00000055931 ENSMUSP00000057346
ENSMUST00000109996 ENSMUSP00000105624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0006612 protein targeting to membrane
GO:0006626 protein targeting to mitochondrion
GO:0016311 dephosphorylation
GO:0033365 protein localization to organelle
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0046677 response to antibiotic
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0031304 intrinsic to mitochondrial inner membrane
GO:0031314 extrinsic component of mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167065
View Gene Order
ENSBTAG00000017459
Not yet available
Cross-References
SwissProt Q8VE01
TrEMBL Q8BWD7
UniProt Splice Variant
Entrez Gene 75219
UniGene Mm.32588 Mm.407847 Mm.417502
RefSeq NM_173745 XM_006514873
OMIM
CCDS CCDS24369
HPRD
IMGT
MGI ID MGI:1922469
MGI Symbol Dusp18
EMBL AK015917 AK052827 AK081916 AL731853 BC020036
GenPept AAH20036 BAC25470 BAC35164 BAC38371 CAI51861
RNA Seq Atlas 75219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca