Version 5.4
Mus musculus Gene: Xiap
Summary
InnateDB Gene IDBG-141324.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xiap
Gene Name X-linked inhibitor of apoptosis
Synonyms 1110015C02Rik; Aipa; Api3; Birc4; IAP3; ILP-1; MIHA
Species Mus musculus
Ensembl Gene ENSMUSG00000025860
Encoded Proteins
IDBP-141326
X-linked inhibitor of apoptosis
IDBP-141328
X-linked inhibitor of apoptosis
IDBP-250394
X-linked inhibitor of apoptosis
IDBP-250396
X-linked inhibitor of apoptosis
IDBP-540073
X-linked inhibitor of apoptosis
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21447281
Xiap facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
InnateDB Annotation from Orthologs
Summary
PMID 18769721
[Homo sapiens] XIAP regulates cytosol-specific innate immunity to Listeria infection.
PMID 19667203
[Homo sapiens] XIAP interacts with NOD1 and NOD2 and mediates NOD signalling via interaction with RIPK2.
PMID 19531477
[Homo sapiens] XIAP and its E3 ligase activity promote transforming growth factor-{beta}-mediated NF-kappaB activation during breast cancer progression.
PMID 20406824
[Homo sapiens] X-linked inhibitor of apoptosis protein (XIAP) in a complex with survivin, a physiological substrate for granzyme M (GzmM), act to inhibit caspase activation.
PMID 21447281
[Homo sapiens] XIAP facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
Entrez Gene
Summary The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:42059679-42109656
Strand Forward strand
Band A4
Transcripts
ENSMUST00000055483 ENSMUSP00000061074
ENSMUST00000026978 ENSMUSP00000026978
ENSMUST00000115095 ENSMUSP00000110747
ENSMUST00000115094 ENSMUSP00000110746
ENSMUST00000141316
ENSMUST00000126375 ENSMUSP00000121482
ENSMUST00000150635
ENSMUST00000146874
ENSMUST00000145065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 119 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0097110 scaffold protein binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051402 neuron apoptotic process
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101966
View Gene Order
ENSBTAG00000040350
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_189085
Disease pathway
REACT_217163
SMAC-mediated dissociation of IAP:caspase complexes pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_223052
SMAC-mediated apoptotic response pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_223546
SMAC binds to IAPs pathway
REACT_188257
Signal Transduction pathway
REACT_211477
Apoptotic factor-mediated response pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu05222
Small cell lung cancer pathway
mmu04210
Apoptosis pathway
mmu04510
Focal adhesion pathway
mmu05200
Pathways in cancer pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_1767
SMAC-mediated dissociation of IAP:caspase complexes pathway
REACT_2190
SMAC binds to IAPs pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_666
SMAC-mediated apoptotic response pathway
REACT_11045
Signaling by Wnt pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_963
Apoptotic factor-mediated response pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04210
Apoptosis pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05200
Pathways in cancer pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
bmppathway
BMP receptor signaling
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL A2BGY5
UniProt Splice Variant
Entrez Gene 11798
UniGene Mm.259879 Mm.413756 Mm.470261 Mm.470928
RefSeq NM_009688 XM_006541422 XM_006541423 XM_006541424 XM_006541425 XM_006541426 XM_006541427 XM_006541428
OMIM
CCDS CCDS30098
HPRD
IMGT
MGI ID MGI:107572
MGI Symbol Xiap
EMBL AL672089 BX530028
GenPept
RNA Seq Atlas 11798

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca