InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Agtr1a

Summary

InnateDB Gene

IDBG-141627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agtr1a

Gene Name

angiotensin II receptor, type 1a

Synonyms

1810074K20Rik; AG2S; Agtr-1a; Agtr1; AI551199; Angtr-1a; AT1; AT1a; AT2R1; AT2R1A

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049115

Encoded Proteins

IDBP-141629

angiotensin II receptor, type 1a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144891:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:30336441-30382867

Strand

Forward strand

Band

A3.2

Transcripts

ENSMUST00000066412	ENSMUSP00000070958
ENSMUST00000143181

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001596	angiotensin type I receptor activity
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0019901	protein kinase binding
GO:0031748	D1 dopamine receptor binding
GO:0043621	protein self-association

Biological Process

GO:0001568	blood vessel development
GO:0001822	kidney development
GO:0001921	positive regulation of receptor recycling
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002001	renin secretion into blood stream
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002019	regulation of renal output by angiotensin
GO:0002035	brain renin-angiotensin system
GO:0006885	regulation of pH
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007507	heart development
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0019229	regulation of vasoconstriction
GO:0032930	positive regulation of superoxide anion generation
GO:0034391	regulation of smooth muscle cell apoptotic process
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0042310	vasoconstriction
GO:0042416	dopamine biosynthetic process
GO:0042756	drinking behavior
GO:0042976	activation of Janus kinase activity
GO:0043627	response to estrogen
GO:0045777	positive regulation of blood pressure
GO:0050715	positive regulation of cytokine secretion
GO:0071549	cellular response to dexamethasone stimulus
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031968	organelle outer membrane
GO:0031983	vesicle lumen
GO:0055037	recycling endosome