Version 5.4
Mus musculus Gene: Gp1bb
Summary
InnateDB Gene IDBG-142031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gp1bb
Gene Name glycoprotein Ib, beta polypeptide
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000050761
Encoded Proteins
IDBP-142033
glycoprotein Ib, beta polypeptide
IDBP-625757
glycoprotein Ib, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203618:
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18620319-18622403
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000051160 ENSMUSP00000059270
ENSMUST00000167388 ENSMUSP00000126292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000203618
View Gene Order
ENSBTAG00000039059
Not yet available
Pathways
NETPATH
REACTOME
REACT_245546
GP1b-IX-V activation signalling pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_239392
Intrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_225107
Platelet Adhesion to exposed collagen pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_326
Intrinsic Pathway pathway
REACT_23847
GP1b-IX-V activation signalling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001001999 NM_010327
OMIM
CCDS CCDS28025 CCDS49787
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca