Version 5.4
Mus musculus Gene: Zhx2
Summary
InnateDB Gene IDBG-142054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zhx2
Gene Name zinc fingers and homeoboxes 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000071757
Encoded Proteins
IDBP-142056
zinc fingers and homeoboxes 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178764:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:57694665-57839832
Strand Forward strand
Band D1
Transcripts
ENSMUST00000096430 ENSMUSP00000094164
ENSMUST00000160990
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006402 mRNA catabolic process
GO:0035019 somatic stem cell maintenance
GO:0045665 negative regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178764
View Gene Order
ENSBTAG00000026309
Not yet available
Cross-References
SwissProt Q8C0C0
TrEMBL
UniProt Splice Variant
Entrez Gene 387609
UniGene Mm.36557 Mm.409021
RefSeq NM_199449
OMIM
CCDS CCDS27483
HPRD
IMGT
MGI ID MGI:2683087
MGI Symbol Zhx2
EMBL AB099526 AB099704 AK031782 BC059178
GenPept AAH59178 BAC27546 BAC87710 BAC87712
RNA Seq Atlas 387609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca