InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rheb

Summary

InnateDB Gene

IDBG-142234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rheb

Gene Name

Ras homolog enriched in brain

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028945

Encoded Proteins

IDBP-142236

Ras homolog enriched in brain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24130493

Mycobacterial infection induces expression of Mir155, which promotes the maturation of phagosomes and represses the expression of Rheb by targeting its 3�??UTR

PMID 24282297

The interplay between Tsc1-Rheb-mTOR complex 1 signalling and Myc-dependent metabolism are dynamically regulated during dentritic cell (DC) development, whereas uncontrolled mTORC1 activation impairs DC development.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106615:
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:24802823-24842624

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030787	ENSMUSP00000030787
ENSMUST00000146310
ENSMUST00000154523

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032008	positive regulation of TOR signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005681	spliceosomal complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome