InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il1rn

Summary

InnateDB Gene

IDBG-142372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1rn

Gene Name

interleukin 1 receptor antagonist

Synonyms

F630041P17Rik; IL-1ra

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026981

Encoded Proteins

IDBP-251670

interleukin 1 receptor antagonist

IDBP-251672

interleukin 1 receptor antagonist

IDBP-251674

interleukin 1 receptor antagonist

IDBP-251676

interleukin 1 receptor antagonist

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136689:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:24336853-24351494

Strand

Forward strand

Band

Transcripts

ENSMUST00000114487	ENSMUSP00000110131
ENSMUST00000114486	ENSMUSP00000110130
ENSMUST00000114485	ENSMUSP00000110129
ENSMUST00000114482	ENSMUSP00000110126
ENSMUST00000142093
ENSMUST00000143423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005149	interleukin-1 receptor binding
GO:0005150	interleukin-1, Type I receptor binding
GO:0005151	interleukin-1, Type II receptor binding
GO:0005152	interleukin-1 receptor antagonist activity
GO:0045352	interleukin-1 Type I receptor antagonist activity
GO:0045353	interleukin-1 Type II receptor antagonist activity

Biological Process

GO:0001660	fever generation
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002439	chronic inflammatory response to antigenic stimulus
GO:0006629	lipid metabolic process
GO:0006953	acute-phase response
GO:0007565	female pregnancy
GO:0007613	memory
GO:0010243	response to organonitrogen compound
GO:0014050	negative regulation of glutamate secretion
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0019233	sensory perception of pain
GO:0019752	carboxylic acid metabolic process
GO:0030073	insulin secretion
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043066	negative regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0045837	negative regulation of membrane potential
GO:0051384	response to glucocorticoid
GO:0070555	response to interleukin-1
GO:0070670	response to interleukin-4
GO:0071874	cellular response to norepinephrine stimulus
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome