Version 5.4
Mus musculus Gene: Melk
Summary
InnateDB Gene IDBG-143395.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Melk
Gene Name maternal embryonic leucine zipper kinase
Synonyms AI327312; mKIAA0175; MPK38
Species Mus musculus
Ensembl Gene ENSMUSG00000035683
Encoded Proteins
IDBP-143399
maternal embryonic leucine zipper kinase
IDBP-533125
maternal embryonic leucine zipper kinase
IDBP-537233
maternal embryonic leucine zipper kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165304:
Gene Information
Type Protein coding
Genomic Location Chromosome 4:44300876-44364675
Strand Forward strand
Band B1
Transcripts
ENSMUST00000045607 ENSMUSP00000043806
ENSMUST00000137703 ENSMUSP00000120242
ENSMUST00000125708 ENSMUSP00000118359
ENSMUST00000137759
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009103 lipopolysaccharide biosynthetic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030097 hemopoiesis
GO:0043065 positive regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165304
View Gene Order
ENSBTAG00000021686
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_010790
OMIM
CCDS CCDS18124
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca