Mus musculus Gene: Serpinb6a
Summary
InnateDB Gene IDBG-143524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinb6a
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 6a
Synonyms 4930482L21Rik; D330015H01Rik; ovalbumin; PI-6; Serpinb6; Spi3;
Species Mus musculus
Ensembl Gene ENSMUSG00000060147
Encoded Proteins
serine (or cysteine) peptidase inhibitor, clade B, member 6c
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
serine (or cysteine) peptidase inhibitor, clade B, member 6a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124570:
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:33917918-34002794
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000076532 ENSMUSP00000075848
ENSMUST00000017188 ENSMUSP00000017188
ENSMUST00000043552 ENSMUSP00000041016
ENSMUST00000171951
ENSMUST00000171034 ENSMUSP00000132433
ENSMUST00000167260 ENSMUSP00000127768
ENSMUST00000171252 ENSMUSP00000126162
ENSMUST00000168350 ENSMUSP00000130356
ENSMUST00000171985
ENSMUST00000164627 ENSMUSP00000127224
ENSMUST00000168400 ENSMUSP00000126450
ENSMUST00000170991 ENSMUSP00000131900
ENSMUST00000166354 ENSMUSP00000126287
ENSMUST00000167237 ENSMUSP00000128267
ENSMUST00000167597
ENSMUST00000170620
ENSMUST00000167163 ENSMUSP00000131115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0008406 gonad development
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Amoebiasis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Dissolution of Fibrin Clot pathway
Hemostasis pathway
KEGG
Amoebiasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.252210
RefSeq NM_001164117 NM_001164118 NM_001243192 NM_009254 XM_006516623 XM_006516624
OMIM
CCDS CCDS26441 CCDS49228
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas