Mus musculus Gene: Nqo2
Summary
InnateDB Gene IDBG-143608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nqo2
Gene Name NAD(P)H dehydrogenase, quinone 2
Synonyms NMO2; Nmor2; Ox2;
Species Mus musculus
Ensembl Gene ENSMUSG00000046949
Encoded Proteins
NAD(P)H dehydrogenase, quinone 2
NAD(P)H dehydrogenase, quinone 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124588:
NQO2 (EC 1.10.99.2) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu et al., 1997 [PubMed 9367528]).[supplied by OMIM, Jul 2010]
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:33964659-33988465
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000021843 ENSMUSP00000021843
ENSMUST00000058978 ENSMUSP00000053809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001512 dihydronicotinamide riboside quinone reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007613 memory
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q9JI75
TrEMBL
UniProt Splice Variant
Entrez Gene 18105
UniGene Mm.264036
RefSeq NM_001163239 NM_001163241 NM_001163242 NM_020282 XM_006516574
OMIM
CCDS CCDS26442
HPRD
IMGT
MGI ID MGI:104513
MGI Symbol Nqo2
EMBL AF252260 AF254076 AF254077 AF254078 AF254079 AF254080 AF254081 AK010842 BC027629
GenPept AAF97785 AAF97789 AAH27629 BAB27217
RNA Seq Atlas 18105