Version 5.4
Mus musculus Gene: Trim28
Summary
InnateDB Gene IDBG-143983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim28
Gene Name tripartite motif-containing 28
Synonyms AA408787; KAP-1; KRIP-1; MommeD9; Tif1b; Tif1beta
Species Mus musculus
Ensembl Gene ENSMUSG00000005566
Encoded Proteins
IDBP-143985
tripartite motif-containing 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22995936
[Homo sapiens] TRIM28 interacts with IRF5 and mediates heterochromatinization at M1 macrophage markers (e.g. TNF) to suppress transcription.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130726:
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13024152-13031035
Strand Forward strand
Band A1
Transcripts
ENSMUST00000005705 ENSMUSP00000005705
ENSMUST00000142421
ENSMUST00000148354
ENSMUST00000128951
ENSMUST00000123603
ENSMUST00000149061
ENSMUST00000125136
ENSMUST00000129122
ENSMUST00000123778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 139 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 85 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 139 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0035851 Krueppel-associated box domain binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0070087 chromo shadow domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001837 epithelial to mesenchymal transition
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0016567 protein ubiquitination
GO:0016925 protein sumoylation
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045087 innate immune response
GO:0045739 positive regulation of DNA repair
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0051259 protein oligomerization
GO:0060028 convergent extension involved in axis elongation
GO:0060669 embryonic placenta morphogenesis
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0000785 chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005719 nuclear euchromatin
GO:0005720 nuclear heterochromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130726
View Gene Order
ENSBTAG00000006422
Not yet available
Pathways
NETPATH
REACTOME
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
cmyb_pathway
C-MYB transcription factor network
e2f_pathway
E2F transcription factor network
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.15701 Mm.489366
RefSeq NM_011588
OMIM
CCDS CCDS20823
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca