Version 5.4
Mus musculus Gene: Insig1
Summary
InnateDB Gene IDBG-144021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insig1
Gene Name insulin induced gene 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000045294
Encoded Proteins
IDBP-144023
insulin induced gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25526307
[Homo sapiens] Upon cytoplasmic DNA stimulation, the endoplasmic reticulum protein AMFR is recruited to and interacts with TMEM173 in an INSIG1-dependent manner.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186480:
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:28071363-28078662
Strand Forward strand
Band B1
Transcripts
ENSMUST00000059155 ENSMUSP00000061877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0006991 response to sterol depletion
GO:0008203 cholesterol metabolic process
GO:0010894 negative regulation of steroid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0032933 SREBP signaling pathway
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045599 negative regulation of fat cell differentiation
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0060021 palate development
GO:0060363 cranial suture morphogenesis
GO:1901303 negative regulation of cargo loading into COPII-coated vesicle
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0032937 SREBP-SCAP-Insig complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186480
View Gene Order
ENSBTAG00000001592
Not yet available
Pathways
NETPATH
REACTOME
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_208174
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30221 Mm.381316 Mm.470370
RefSeq NM_153526
OMIM
CCDS CCDS19142
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca