Version 5.4
Mus musculus Gene: Kremen2
Summary
InnateDB Gene IDBG-144068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kremen2
Gene Name kringle containing transmembrane protein 2
Synonyms 2900054E04Rik; Krm2
Species Mus musculus
Ensembl Gene ENSMUSG00000040680
Encoded Proteins
IDBP-144070
kringle containing transmembrane protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131650:
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:23741200-23745829
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000046525 ENSMUSP00000046369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131650
View Gene Order
ENSBTAG00000020190
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_210612
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200643
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q8K1S7
TrEMBL
UniProt Splice Variant
Entrez Gene 73016
UniGene Mm.221319
RefSeq NM_028416 XM_006524983 XM_006524984
OMIM
CCDS CCDS28462
HPRD
IMGT
MGI ID MGI:1920266
MGI Symbol Kremen2
EMBL AJ457192 BC120532 BC125438
GenPept AAI20533 AAI25439 CAD29805
RNA Seq Atlas 73016

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca