InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ewsr1

Summary

InnateDB Gene

IDBG-144115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ewsr1

Gene Name

Ewing sarcoma breakpoint region 1

Synonyms

Ews; Ewsh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009079

Encoded Proteins

IDBP-144117

Ewing sarcoma breakpoint region 1

IDBP-144119

Ewing sarcoma breakpoint region 1

IDBP-144121

Ewing sarcoma breakpoint region 1

IDBP-144123

Ewing sarcoma breakpoint region 1

IDBP-144125

Ewing sarcoma breakpoint region 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182944:
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:5069689-5099266

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102930	ENSMUSP00000099994
ENSMUST00000073308	ENSMUSP00000073034
ENSMUST00000079949	ENSMUSP00000078867
ENSMUST00000093365	ENSMUSP00000091057
ENSMUST00000063232	ENSMUSP00000066827
ENSMUST00000130118
ENSMUST00000130060
ENSMUST00000141002
ENSMUST00000151497
ENSMUST00000150168
ENSMUST00000139886
ENSMUST00000144238
ENSMUST00000151847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 184 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	184 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000182944

View Gene Order

ENSBTAG00000017755

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.388349 Mm.399275

RefSeq

NM_001283061 NM_001283062 NM_007968 XM_006514508 XM_006514509 XM_006514510 XM_006514511 XM_006514512 XM_006514513

OMIM

CCDS

CCDS24396 CCDS70131

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas