Version 5.4
Mus musculus Gene: Myc
Summary
InnateDB Gene IDBG-144556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myc
Gene Name myelocytomatosis oncogene
Synonyms AU016757; bHLHe39; Myc2; Niard; Nird
Species Mus musculus
Ensembl Gene ENSMUSG00000022346
Encoded Proteins
IDBP-144558
myelocytomatosis oncogene
IDBP-533866
myelocytomatosis oncogene
IDBP-533087
myelocytomatosis oncogene
IDBP-533134
myelocytomatosis oncogene
IDBP-532371
myelocytomatosis oncogene
IDBP-621836
myelocytomatosis oncogene
IDBP-788588
myelocytomatosis oncogene
IDBP-788589
myelocytomatosis oncogene
IDBP-788590
myelocytomatosis oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25049387
Pituitary hormone prolactin (Prl) constrains tumor-promoting liver inflammation by inhibiting Map3k1-dependent activation of Myc at the level of the trafasome.
Entrez Gene
Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:61985341-61990374
Strand Forward strand
Band D1
Transcripts
ENSMUST00000022971 ENSMUSP00000022971
ENSMUST00000161976 ENSMUSP00000123821
ENSMUST00000159327 ENSMUSP00000124758
ENSMUST00000159338 ENSMUSP00000125480
ENSMUST00000160009 ENSMUSP00000123852
ENSMUST00000167731 ENSMUSP00000130285
ENSMUST00000188482 ENSMUSP00000140183
ENSMUST00000191178 ENSMUSP00000141139
ENSMUST00000188722 ENSMUSP00000140760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 676 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 26 [view]
Protein-DNA 38 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 676 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001783 B cell apoptotic process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002082 regulation of oxidative phosphorylation
GO:0002904 positive regulation of B cell apoptotic process
GO:0006006 glucose metabolic process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006848 pyruvate transport
GO:0006865 amino acid transport
GO:0006879 cellular iron ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007007 inner mitochondrial membrane organization
GO:0007346 regulation of mitotic cell cycle
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009100 glycoprotein metabolic process
GO:0009314 response to radiation
GO:0009611 response to wounding
GO:0009812 flavonoid metabolic process
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0016055 Wnt signaling pathway
GO:0016485 protein processing
GO:0019087 transformation of host cell by virus
GO:0021854 hypothalamus development
GO:0032091 negative regulation of protein binding
GO:0032204 regulation of telomere maintenance
GO:0032355 response to estradiol
GO:0035690 cellular response to drug
GO:0035914 skeletal muscle cell differentiation
GO:0042474 middle ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043279 response to alkaloid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043473 pigmentation
GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045023 G0 to G1 transition
GO:0045087 innate immune response (InnateDB)
GO:0045656 negative regulation of monocyte differentiation
GO:0045787 positive regulation of cell cycle
GO:0045821 positive regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046325 negative regulation of glucose import
GO:0046722 lactic acid secretion
GO:0048146 positive regulation of fibroblast proliferation
GO:0048705 skeletal system morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0051276 chromosome organization
GO:0051782 negative regulation of cell division
GO:0060070 canonical Wnt signaling pathway
GO:0060548 negative regulation of cell death
GO:0071322 cellular response to carbohydrate stimulus
GO:0071347 cellular response to interleukin-1
GO:0071391 cellular response to estrogen stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071464 cellular response to hydrostatic pressure
GO:0071966 fungal-type cell wall polysaccharide metabolic process
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation
GO:1901857 positive regulation of cellular respiration
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0016604 nuclear body
GO:0030424 axon
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136997
View Gene Order
ENSBTAG00000008409
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_188804
Cell Cycle pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_253623
S Phase pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu05219
Bladder cancer pathway
mmu04012
ErbB signaling pathway pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu05216
Thyroid cancer pathway
mmu04110
Cell cycle pathway
mmu04010
MAPK signaling pathway pathway
mmu05222
Small cell lung cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_200799
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_899
S Phase pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_1783
G1/S Transition pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_225014
S Phase pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_211609
G1/S Transition pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214934
Cell Cycle pathway
REACT_226495
Cyclin E associated events during G1/S transition pathway
REACT_206864
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04010
MAPK signaling pathway pathway
hsa05216
Thyroid cancer pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa05222
Small cell lung cancer pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
cd40_pathway
CD40/CD40L signaling
ceramide_pathway
Ceramide signaling pathway
il2_1pathway
IL2-mediated signaling events
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ps1pathway
Presenilin action in Notch and Wnt signaling
myc_represspathway
Validated targets of C-MYC transcriptional repression
myc_activpathway
Validated targets of C-MYC transcriptional activation
lkb1_pathway
LKB1 signaling events
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ap1_pathway
AP-1 transcription factor network
p73pathway
p73 transcription factor network
cmyb_pathway
C-MYB transcription factor network
e2f_pathway
E2F transcription factor network
myc_pathway
C-MYC pathway
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
foxm1pathway
FOXM1 transcription factor network
il2_pi3kpathway
IL2 signaling events mediated by PI3K
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
telomerasepathway
Regulation of Telomerase
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL E0CZD1 F8WID3 Q6WDF1 Q8K3Z5
UniProt Splice Variant
Entrez Gene 17869
UniGene
RefSeq NM_010849 NM_001177352 NM_001177353 NM_001177354
OMIM
CCDS CCDS27504 CCDS49614 CCDS49615
HPRD
IMGT
MGI ID MGI:97250
MGI Symbol Myc
EMBL AC134611 AF519452 AK087961 AK133952 AK145084 AY294976 BC006728 K00683 L00038 L00039 X01023
GenPept AAB59728 AAH06728 AAN03877 AAQ57173 BAC40060 BAE21948 BAE26228 CAA25508
RNA Seq Atlas 17869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca