Mus musculus Gene: Zap70
Summary
InnateDB Gene IDBG-145089.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zap70
Gene Name zeta-chain (TCR) associated protein kinase
Synonyms mrtle; mur; Srk; ZAP-70;
Species Mus musculus
Ensembl Gene ENSMUSG00000026117
Encoded Proteins
zeta-chain (TCR) associated protein kinase
zeta-chain (TCR) associated protein kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:36761798-36782816
Strand Forward strand
Band B
Transcripts
ENSMUST00000027291 ENSMUSP00000027291
ENSMUST00000185871 ENSMUSP00000139990
ENSMUST00000186624
ENSMUST00000190128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0035556 intracellular signal transduction
GO:0043366 beta selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045061 thymic T cell selection
GO:0045582 positive regulation of T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0042101 T cell receptor complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Immune System pathway
Translocation of ZAP-70 to Immunological synapse pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
KEGG
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
INOH
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
BCR pathway
Prolactin pathway
REACTOME
TCR signaling pathway
Adaptive Immune System pathway
Immune System pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
KEGG
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
INOH
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Role of mef2d in t-cell apoptosis [Biocarta view]
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001289612 NM_001289765 NM_001289766 NM_009539 XM_006495896 XM_006495897
OMIM
CCDS CCDS14888
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas