Homo sapiens Gene: CHD4
Summary
InnateDB Gene IDBG-14532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHD4
Gene Name chromodomain helicase DNA binding protein 4
Synonyms CHD-4; Mi-2b; Mi2-BETA;
Species Homo sapiens
Ensembl Gene ENSG00000111642
Encoded Proteins
chromodomain helicase DNA binding protein 4
chromodomain helicase DNA binding protein 4
chromodomain helicase DNA binding protein 4
chromodomain helicase DNA binding protein 4
chromodomain helicase DNA binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6570083-6607476
Strand Reverse strand
Band p13.31
Transcripts
ENST00000357008 ENSP00000349508
ENST00000430771
ENST00000544484 ENSP00000440392
ENST00000544040 ENSP00000440542
ENST00000535717
ENST00000542717
ENST00000536301
ENST00000540960
ENST00000537634
ENST00000545083
ENST00000536999
ENST00000535810
ENST00000545942 ENSP00000437506
ENST00000545584 ENSP00000444614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 115 [view]
Protein-Protein 115 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008026 ATP-dependent helicase activity
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008152 metabolic process
GO:0032508 DNA duplex unwinding
GO:0043044 ATP-dependent chromatin remodeling
GO:0051225 spindle assembly
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0016581 NuRD complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Clearance pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
RNA Polymerase I Transcription Initiation pathway
Chromatin modifying enzymes pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Cross-References
SwissProt Q14839
TrEMBL
UniProt Splice Variant
Entrez Gene 1108
UniGene Hs.162233 Hs.605320
RefSeq XM_006718958 NM_001273 NM_001297553 XM_006718960 XM_006718959 XM_005253668 XM_006718961
HUGO HGNC:1919
OMIM 603277
CCDS CCDS8552
HPRD 04472
IMGT
EMBL AC006064 BC038596 X86691
GenPept AAH38596 CAA60384
RNA Seq Atlas 1108