Version 5.4
Homo sapiens Gene: ESCO2
Summary
InnateDB Gene IDBG-14554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESCO2
Gene Name establishment of cohesion 1 homolog 2 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171320
Encoded Proteins
IDBP-14556
establishment of cohesion 1 homolog 2 (S. cerevisiae)
IDBP-235417
establishment of cohesion 1 homolog 2 (S. cerevisiae)
IDBP-482361
establishment of cohesion 1 homolog 2 (S. cerevisiae)
IDBP-480572
establishment of cohesion 1 homolog 2 (S. cerevisiae)
IDBP-479462
establishment of cohesion 1 homolog 2 (S. cerevisiae)
IDBP-479826
establishment of cohesion 1 homolog 2 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:27771949-27812640
Strand Forward strand
Band p21.1
Transcripts
ENST00000305188 ENSP00000306999
ENST00000397418 ENSP00000380563
ENST00000523566 ENSP00000428435
ENST00000522378 ENSP00000428928
ENST00000519637 ENSP00000428027
ENST00000524293
ENST00000523910
ENST00000518262 ENSP00000428959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004468 lysine N-acetyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006275 regulation of DNA replication
GO:0006302 double-strand break repair
GO:0007059 chromosome segregation
GO:0034421 post-translational protein acetylation
GO:0071168 protein localization to chromatin
Cellular Component
GO:0000785 chromatin
GO:0001741 XY body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0010369 chromocenter
GO:0031618 nuclear centromeric heterochromatin
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022034
View Gene Order
ENSBTAG00000006551
Not yet available
Pathways
NETPATH
REACTOME
REACT_150266
Establishment of Sister Chromatid Cohesion pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E5RFP7
UniProt Splice Variant
Entrez Gene 157570
UniGene Hs.599826 Hs.99480
RefSeq NM_001017420 XM_006716297
HUGO HGNC:27230
OMIM 609353
CCDS CCDS34872
HPRD 18564
IMGT
EMBL AC104997
GenPept
RNA Seq Atlas 157570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca