Version 5.4
Mus musculus Gene: Abp1
Summary
InnateDB Gene IDBG-145895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abp1
Gene Name amiloride binding protein 1 (amine oxidase, copper-containing)
Synonyms 1600012D06Rik; Abp1; DAO
Species Mus musculus
Ensembl Gene ENSMUSG00000029811
Encoded Proteins
IDBP-145897
amiloride binding protein 1 (amine oxidase, copper-containing)
IDBP-533285
amiloride binding protein 1 (amine oxidase, copper-containing)
IDBP-627434
amiloride binding protein 1 (amine oxidase, copper-containing)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002726:
This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:48895254-48909188
Strand Forward strand
Band B2.3
Transcripts
ENSMUST00000031835 ENSMUSP00000031835
ENSMUST00000162948 ENSMUSP00000124085
ENSMUST00000161184
ENSMUST00000167529 ENSMUSP00000128816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005261 cation channel activity
GO:0005507 copper ion binding
GO:0008131 primary amine oxidase activity
GO:0008144 drug binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0032403 protein complex binding
GO:0048038 quinone binding
GO:0052597 diamine oxidase activity
GO:0052598 histamine oxidase activity
GO:0052599 methylputrescine oxidase activity
GO:0052600 propane-1,3-diamine oxidase activity
Biological Process
GO:0006812 cation transport
GO:0009308 amine metabolic process
GO:0035874 cellular response to copper ion starvation
GO:0042493 response to drug
GO:0046677 response to antibiotic
GO:0055114 oxidation-reduction process
GO:0071280 cellular response to copper ion
GO:0071420 cellular response to histamine
GO:0097185 cellular response to azide
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005923 tight junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000002726
View Gene Order
ENSBTAG00000005419
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00340
Histidine metabolism pathway
mmu00330
Arginine and proline metabolism pathway
mmu00380
Tryptophan metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00340
Histidine metabolism pathway
hsa00330
Arginine and proline metabolism pathway
hsa00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Phenylalanine degradation pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Tyrosine metabolism pathway
INOH website
Glycine Serine metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt Q8JZQ5
TrEMBL E9PYN9 Q9CW16
UniProt Splice Variant
Entrez Gene 76507
UniGene Mm.213898
RefSeq NM_001161622 XM_006506736 NM_001161621 NM_029638
OMIM
CCDS CCDS51767
HPRD
IMGT
MGI ID MGI:1923757
MGI Symbol Aoc1
EMBL AC159547 AK005423 BC021880 BC022627 BC034215
GenPept AAH21880 AAH22627 AAH34215 BAB24017
RNA Seq Atlas 76507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca