InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Igf2bp3

Summary

InnateDB Gene

IDBG-146190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igf2bp3

Gene Name

insulin-like growth factor 2 mRNA binding protein 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029814

Encoded Proteins

IDBP-146192

insulin-like growth factor 2 mRNA binding protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136231:
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5\' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:49085221-49214954

Strand

Reverse strand

Band

B2.3

Transcripts

ENSMUST00000031838

ENSMUSP00000031838

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006417	regulation of translation
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136231

View Gene Order

ENSBTAG00000019406

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22166

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9CPN8

TrEMBL

UniProt Splice Variant

Entrez Gene

140488

UniGene

Mm.281018 Mm.415812

RefSeq

NM_023670

OMIM

CCDS

CCDS39485

HPRD

IMGT

MGI ID

MGI:1890359

MGI Symbol

Igf2bp3

EMBL

AK011689 AK088465 AK147140 BC045138 BC049082

GenPept

AAH45138 AAH49082 BAB27779 BAC40370 BAE27710

RNA Seq Atlas

140488