Homo sapiens Gene: SOCS1
Summary
InnateDB Gene IDBG-14621.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS1
Gene Name suppressor of cytokine signaling 1
Synonyms CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3;
Species Homo sapiens
Ensembl Gene ENSG00000185338
Encoded Proteins
suppressor of cytokine signaling 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SOCS1 is a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
SOCS1 regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human monocytes and macrophages.
SOCS1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signalling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.
SOCS1 is targeted by endogenous and pharmacologic glucocorticoids to limit TLR3/TLR4-mediated STAT1 activation which results in the suppression of inflammation. (Demonstrated in murine model)
SOCS1 inhibits type I interferon (IFN) signaling through an interaction with the IFNAR1 associated kinase, TYK2, resulting in a reduced IFN response and reduced IFNAR1 surface expression.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Socs1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.
[Mus musculus] Socs1 is targeted by endogenous and pharmacologic glucocorticoids to limit Tlr3/Tlr4-mediated Stat1 activation which results in the suppression of inflammation.
[Mus musculus] Socs1 inhibits type I interferon (IFN) signaling through an interaction with the Ifnar1 associated kinase, Tyk2, resulting in a reduced IFN response and reduced Ifnar1 surface expression. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:11254405-11256179
Strand Reverse strand
Band p13.13
Transcripts
ENST00000332029 ENSP00000329418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 75 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019901 protein kinase binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007259 JAK-STAT cascade
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
IL2 pathway
IL4 pathway
IL5 pathway
TSH pathway
Prolactin pathway
REACTOME
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by SCF-KIT pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Regulation of IFNA signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Growth hormone receptor signaling pathway
Interferon gamma signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Regulation of IFNG signaling pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of KIT signaling pathway
KEGG
Ubiquitin mediated proteolysis pathway
Osteoclast differentiation pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Toxoplasmosis pathway
INOH
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
PID BIOCARTA
Il-2 receptor beta chain in t cell activation [Biocarta view]
PID NCI
IL2-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
IFN-gamma pathway
Cross-References
SwissProt O15524
TrEMBL Q4JHT5
UniProt Splice Variant
Entrez Gene 8651
UniGene Hs.50640
RefSeq NM_003745
HUGO HGNC:19383
OMIM 603597
CCDS CCDS10546
HPRD
IMGT
EMBL AB000676 AB000734 AB005043 AF132440 AK127621 CH471112 DQ086801 U88326 Z46940
GenPept AAB62401 AAD27709 AAY87931 BAA21537 BAA22431 BAA23521 BAG54535 CAB92528 EAW85163
RNA Seq Atlas 8651