InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Edf1

Summary

InnateDB Gene

IDBG-146359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edf1

Gene Name

endothelial differentiation-related factor 1

Synonyms

0610008L11Rik; AA409425

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015092

Encoded Proteins

IDBP-146361

endothelial differentiation-related factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107223:
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:25557847-25562082

Strand

Forward strand

Band

Transcripts

ENSMUST00000015236	ENSMUSP00000015236
ENSMUST00000153008
ENSMUST00000134689
ENSMUST00000144395
ENSMUST00000142288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043388	positive regulation of DNA binding

Cellular Component

GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107223

View Gene Order

ENSBTAG00000030302

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_021519 XM_006542935 XM_979372

OMIM

CCDS

CCDS15780

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas