Mus musculus Gene: Edf1
Summary
InnateDB Gene IDBG-146359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Edf1
Gene Name endothelial differentiation-related factor 1
Synonyms 0610008L11Rik; AA409425;
Species Mus musculus
Ensembl Gene ENSMUSG00000015092
Encoded Proteins
endothelial differentiation-related factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107223:
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25557847-25562082
Strand Forward strand
Band A3
Transcripts
ENSMUST00000015236 ENSMUSP00000015236
ENSMUST00000153008
ENSMUST00000134689
ENSMUST00000144395
ENSMUST00000142288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0043388 positive regulation of DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q9JMG1
TrEMBL
UniProt Splice Variant
Entrez Gene 665181
UniGene
RefSeq NM_021519 XM_006542935 XM_979372
OMIM
CCDS CCDS15780
HPRD
IMGT
MGI ID MGI:1891227
MGI Symbol Edf1
EMBL AB030185 AJ309569 AK002345 AK003557 AK010191 BC023472
GenPept AAH23472 BAA92749 BAB22026 BAB22854 BAB26758 CAC32040
RNA Seq Atlas 59022 665181