InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sae1

Summary

InnateDB Gene

IDBG-146412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sae1

Gene Name

SUMO1 activating enzyme subunit 1

Synonyms

2400010M20Rik; 2610044L12Rik; AL033372; AOS1; AW743391; D7Ertd177e; HSPC140; Sua1; Uble1a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052833

Encoded Proteins

IDBP-146414

SUMO1 activating enzyme subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142230:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:16327053-16387797

Strand

Reverse strand

Band

Transcripts

ENSMUST00000094815

ENSMUSP00000092409

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016874	ligase activity
GO:0019948	SUMO activating enzyme activity
GO:0043008	ATP-dependent protein binding