InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grlf1

Summary

InnateDB Gene

IDBG-146714.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grlf1

Gene Name

glucocorticoid receptor DNA binding factor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058230

Encoded Proteins

IDBP-146716

glucocorticoid receptor DNA binding factor 1

IDBP-622573

glucocorticoid receptor DNA binding factor 1

IDBP-788830

Rho GTPase activating protein 35

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160007:
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:16493719-16614993

Strand

Reverse strand

Band

Transcripts

ENSMUST00000075845	ENSMUSP00000075242
ENSMUST00000171937	ENSMUSP00000127379
ENSMUST00000188133	ENSMUSP00000139912

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005096	GTPase activator activity
GO:0005525	GTP binding

Biological Process

GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030900	forebrain development
GO:0043010	camera-type eye development
GO:0043116	negative regulation of vascular permeability
GO:0043547	positive regulation of GTPase activity
GO:0045892	negative regulation of transcription, DNA-templated