Version 5.4
| Mus musculus Gene: Wisp1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-146803.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Wisp1 | ||||||||
| Gene Name | WNT1 inducible signaling pathway protein 1 | ||||||||
| Synonyms | AW146261; CCN4; Elm1 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000005124 | ||||||||
| Encoded Proteins |
WNT1 inducible signaling pathway protein 1
WNT1 inducible signaling pathway protein 1
WNT1 inducible signaling pathway protein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104415:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 15:66891320-66923201 | ||||||||
| Strand | Forward strand | ||||||||
| Band | D2 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | O54775 | ||||||||
| TrEMBL | D3Z6X6 Q3UFJ5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 22402 | ||||||||
| UniGene | Mm.10222 | ||||||||
| RefSeq | NM_018865 XM_006520889 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS27510 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1197008 | ||||||||
| MGI Symbol | Wisp1 | ||||||||
| EMBL | AB004873 AC107859 AF100777 AK148457 BC048791 BC052677 | ||||||||
| GenPept | AAC96319 AAH48791 AAH52677 BAA24949 BAE28565 | ||||||||
| RNA Seq Atlas | 22402 | ||||||||