Version 5.4
Mus musculus Gene: Ndrg1
Summary
InnateDB Gene IDBG-146853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndrg1
Gene Name N-myc downstream regulated gene 1
Synonyms CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl; NMSL; PROXY1; RTP; TDD5
Species Mus musculus
Ensembl Gene ENSMUSG00000005125
Encoded Proteins
IDBP-146855
N-myc downstream regulated gene 1
IDBP-622836
N-myc downstream regulated gene 1
IDBP-622838
N-myc downstream regulated gene 1
IDBP-622839
N-myc downstream regulated gene 1
IDBP-622842
N-myc downstream regulated gene 1
IDBP-622843
N-myc downstream regulated gene 1
IDBP-622845
N-myc downstream regulated gene 1
IDBP-622847
N-myc downstream regulated gene 1
IDBP-622849
N-myc downstream regulated gene 1
IDBP-622850
N-myc downstream regulated gene 1
IDBP-622851
N-myc downstream regulated gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104419:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:66929321-66969640
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000005256 ENSMUSP00000005256
ENSMUST00000165966
ENSMUST00000166420 ENSMUSP00000127099
ENSMUST00000171569
ENSMUST00000164675 ENSMUSP00000130150
ENSMUST00000168542 ENSMUSP00000127940
ENSMUST00000167817 ENSMUSP00000127075
ENSMUST00000168979 ENSMUSP00000126985
ENSMUST00000172447 ENSMUSP00000130281
ENSMUST00000171266 ENSMUSP00000129093
ENSMUST00000170903 ENSMUSP00000127302
ENSMUST00000163496 ENSMUSP00000130584
ENSMUST00000164070 ENSMUSP00000126091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 73 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0017137 Rab GTPase binding
GO:0043015 gamma-tubulin binding
GO:0045296 cadherin binding
Biological Process
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032287 peripheral nervous system myelin maintenance
GO:0045576 mast cell activation
GO:0071456 cellular response to hypoxia
GO:0090232 positive regulation of spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0015630 microtubule cytoskeleton
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104419
View Gene Order
ENSBTAG00000000711
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
myc_represspathway
Validated targets of C-MYC transcriptional repression
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30837
RefSeq NM_008681 XM_006520568
OMIM
CCDS CCDS37092
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca