Mus musculus Gene: Hnrnpa2b1
Summary
InnateDB Gene IDBG-147385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpa2b1
Gene Name heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms 9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1;
Species Mus musculus
Ensembl Gene ENSMUSG00000004980
Encoded Proteins
heterogeneous nuclear ribonucleoprotein A2/B1
heterogeneous nuclear ribonucleoprotein A2/B1
heterogeneous nuclear ribonucleoprotein A2/B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122566:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:51460434-51469894
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000090002 ENSMUSP00000087453
ENSMUST00000069949 ENSMUSP00000067491
ENSMUST00000114459 ENSMUSP00000110103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043047 single-stranded telomeric DNA binding
GO:0044822 poly(A) RNA binding
GO:0097157 pre-mRNA intronic binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0050658 RNA transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing pathway
Gene Expression pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O88569
TrEMBL
UniProt Splice Variant
Entrez Gene 53379
UniGene Mm.155896 Mm.407593
RefSeq NM_182650 NM_016806 XM_006506372 XM_006544755
OMIM
CCDS CCDS51773 CCDS51774
HPRD
IMGT
MGI ID MGI:104819
MGI Symbol Hnrnpa2b1
EMBL AF073990 AF073993 AF406651 AF452567 AK089012 AK137214 BC059107 BC141253
GenPept AAC26867 AAD29846 AAH59107 AAI41254 AAK98601 AAN16352 BAC40700 BAE23274
RNA Seq Atlas 102642938 53379