Version 5.4
Mus musculus Gene: Arhgef6
Summary
InnateDB Gene IDBG-147466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef6
Gene Name Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Synonyms 1600028C08Rik; 1700038J06Rik; 4930592P22Rik; alpha-PIX
Species Mus musculus
Ensembl Gene ENSMUSG00000031133
Encoded Proteins
IDBP-147468
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
IDBP-251135
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
IDBP-715694
IDBP-715428
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129675:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:57231485-57338729
Strand Reverse strand
Band A6
Transcripts
ENSMUST00000033468 ENSMUSP00000033468
ENSMUST00000114735 ENSMUSP00000110383
ENSMUST00000151768
ENSMUST00000134028
ENSMUST00000135098
ENSMUST00000175636
ENSMUST00000176986 ENSMUSP00000134851
ENSMUST00000175900 ENSMUSP00000135475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030032 lamellipodium assembly
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129675
View Gene Order
ENSBTAG00000017850
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_210090
Rho GTPase cycle pathway
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_241978
Cell junction organization pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_223082
Cell-Cell communication pathway
REACT_255191
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu05212
Pancreatic cancer pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_11061
Signalling by NGF pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05212
Pancreatic cancer pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
ilk_pathway
Integrin-linked kinase signaling
cdc42_pathway
CDC42 signaling events
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.261443
RefSeq NM_152801 XM_006528313 XM_006528317
OMIM
CCDS CCDS40984
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca