InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fli1

Summary

InnateDB Gene

IDBG-147469.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fli1

Gene Name

Friend leukemia integration 1

Synonyms

EWSR2; Fli-1; SIC-1; Sic1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016087

Encoded Proteins

IDBP-147471

Friend leukemia integration 1

IDBP-788799

Friend leukemia integration 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20879862

[Homo sapiens] FLI1 contributes to lipopolysaccharide (LPS)-induced expression of matrix metalloprotease 1 (MMP-1), MMP-3, MMP-10, and interleukin-10 (IL-10) and rapid down-regulation of FLI1 expression after LPS stimulation attenuates the induction of various MMPs and IL-10 under inflammatory conditions.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151702:
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:32422204-32542861

Strand

Reverse strand

Band

Transcripts

ENSMUST00000016231	ENSMUSP00000016231
ENSMUST00000183767	ENSMUSP00000138984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	2 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008015	blood circulation
GO:0009887	organ morphogenesis
GO:0009987	cellular process
GO:0035855	megakaryocyte development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151702

View Gene Order

ENSBTAG00000008283

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

INOH website

FGF8 signaling (Mouse) pathway

INOH website

FGF signaling pathway pathway

PID NCI

Cross-References

SwissProt

TrEMBL

V9GX50

UniProt Splice Variant

Entrez Gene

14247

UniGene

RefSeq

NM_008026 XM_006510009

OMIM

CCDS

CCDS40571

HPRD

IMGT

MGI ID

MGI:95554

MGI Symbol

Fli1

EMBL

AC127581 AC141646

GenPept

RNA Seq Atlas

14247