InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rap2b

Summary

InnateDB Gene

IDBG-147645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rap2b

Gene Name

RAP2B, member of RAS oncogene family

Synonyms

4021402C18Rik; AA408554

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036894

Encoded Proteins

IDBP-147647

RAP2B, member of RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181467:
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50%% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:61364507-61368703

Strand

Forward strand

Band

Transcripts

ENSMUST00000049064

ENSMUSP00000038841

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030336	negative regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032486	Rap protein signal transduction
GO:0061097	regulation of protein tyrosine kinase activity

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000181467

View Gene Order

ENSBTAG00000016961

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.422674 Mm.460486 Mm.477648

RefSeq

NM_028712

OMIM

CCDS

CCDS17378

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas