InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Senp2

Summary

InnateDB Gene

IDBG-147701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Senp2

Gene Name

SUMO/sentrin specific peptidase 2

Synonyms

2310007L05Rik; 4930538C18Rik; AI646780; AW554757; mKIAA1331; Smt3ip2; SuPr-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022855

Encoded Proteins

IDBP-147703

SUMO/sentrin specific peptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22028379

Senp2 acts as a negative regulator of virus-triggered IFN-beta induction by deSUMOylating Irf3 and conditioning it for ubiquitination and degradation.

InnateDB Annotation from Orthologs

Summary

PMID 22028379

[Homo sapiens] SENP2 acts as a negative regulator of virus-triggered IFN-beta induction by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163904:
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:22009484-22049269

Strand

Forward strand

Band

Transcripts

ENSMUST00000023561

ENSMUSP00000023561

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016929	SUMO-specific protease activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006508	proteolysis
GO:0007507	heart development
GO:0009950	dorsal/ventral axis specification
GO:0015031	protein transport
GO:0016055	Wnt signaling pathway
GO:0016926	protein desumoylation
GO:0032091	negative regulation of protein binding
GO:0032875	regulation of DNA endoreduplication
GO:0035562	negative regulation of chromatin binding
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051028	mRNA transport
GO:0051246	regulation of protein metabolic process
GO:0060707	trophoblast giant cell differentiation
GO:0060711	labyrinthine layer development
GO:0060712	spongiotrophoblast layer development
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016604	nuclear body
GO:0016605	PML body
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane