Mus musculus Gene: Mme | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-147991.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mme | ||||||||||||||||||||||
Gene Name | membrane metallo endopeptidase | ||||||||||||||||||||||
Synonyms | 6030454K05Rik; C85356; CALLA; CD10; NEP; SFE | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000027820 | ||||||||||||||||||||||
Encoded Proteins |
membrane metallo endopeptidase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196549:
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85%% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5\' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 3:63295872-63382231 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | E1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Metabolism of proteins pathway
Peptide hormone metabolism pathway
Metabolism of Angiotensinogen to Angiotensins pathway
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KEGG |
Renin-angiotensin system pathway
Alzheimer's disease pathway
Hematopoietic cell lineage pathway
Protein digestion and absorption pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Metabolism of Angiotensinogen to Angiotensins pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
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KEGG |
Renin-angiotensin system pathway
Hematopoietic cell lineage pathway
Alzheimer's disease pathway
Protein digestion and absorption pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q61391 | ||||||||||||||||||||||
TrEMBL | Q8BNU9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17380 | ||||||||||||||||||||||
UniGene | Mm.296022 Mm.422356 | ||||||||||||||||||||||
RefSeq | NM_001289462 NM_001289463 NM_008604 XM_006501095 XM_006501096 XM_006501097 XM_006501098 XM_006501099 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS17381 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:97004 | ||||||||||||||||||||||
MGI Symbol | Mme | ||||||||||||||||||||||
EMBL | AK031446 AK033824 AK080202 BC034092 BC066840 M81591 | ||||||||||||||||||||||
GenPept | AAA37386 AAH34092 AAH66840 BAC27410 BAC28487 BAC37847 | ||||||||||||||||||||||
RNA Seq Atlas | 17380 | ||||||||||||||||||||||