Version 5.4
Mus musculus Gene: Hoxa13
Summary
InnateDB Gene IDBG-148096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxa13
Gene Name homeobox A13
Synonyms Hd; Hox-1.10
Species Mus musculus
Ensembl Gene ENSMUSG00000038203
Encoded Proteins
IDBP-148098
homeobox A13
IDBP-251808
homeobox A13
IDBP-542162
homeobox A13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106031:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:52257694-52260880
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000047993 ENSMUSP00000039170
ENSMUST00000114416 ENSMUSP00000110059
ENSMUST00000147595 ENSMUSP00000125221
ENSMUST00000174763
ENSMUST00000172961
ENSMUST00000173368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001570 vasculogenesis
GO:0001886 endothelial cell morphogenesis
GO:0001894 tissue homeostasis
GO:0003281 ventricular septum development
GO:0006355 regulation of transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0030510 regulation of BMP signaling pathway
GO:0030539 male genitalia development
GO:0035115 embryonic forelimb morphogenesis
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060847 endothelial cell fate specification
GO:2001055 positive regulation of mesenchymal cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106031
View Gene Order
ENSBTAG00000014735
Not yet available
Cross-References
SwissProt
TrEMBL E0CXK7 E9QM91
UniProt Splice Variant
Entrez Gene 15398
UniGene Mm.377086
RefSeq NM_008264
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:96173
MGI Symbol Hoxa13
EMBL AC015583 FQ828346
GenPept
RNA Seq Atlas 15398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca